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Cell 48 , 185191 (1987)

A completed intake does not mean a prescription will be issued

Download the Notable Articles of 2025: nej.md/3L4ot87 In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes

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Interestingly, these neurons were deactivated during consumption, comparable with the activation of DMH GLP-1R neurons during consumption to encode pre-ingestive satiation [48,61]