MingoranceCRodriguez-RodriguezRJustoMLHerreraMDde SotomayorMA
How Retatrutide Fits Among Current Doctor-Prescribed Weight-Loss Medications Retatrutide is being studied as an investigational metabolic therapy that activates three hormonal pathways simultaneously
Additional promising targets include TGF--driven fibrogenic signaling and oxidative stress pathways propagated by advanced glycation end-products and their receptor RAGE (Zhou et al., 2025b), IL-6 neutralization (ziltivekimab), and anti-fibrotic candidates like pirfenidone or ASK1 inhibition (selonsertib) (Figure 6)
No retatrutide does not hold an MHRA marketing authorisation and cannot be legally prescribed or dispensed in the UK outside of authorised clinical trials
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The Wegovy Summary of Product Characteristics lists 'heart rate increased' as an adverse reaction
