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Several types of allelic variation have been identified within classes, with GSTM1 -null, GSTT1 -null and GSTP1-Ile105/Ile105 conferring impaired catalytic activity

The primary endpoint was the percent change in weight from baseline at 72 weeks

Glucose is transported into intestinal L-cells by sodium-glucose cotransporters, and the resultant increase in Ca 2+ influx triggers GLP-1 secretion 32

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