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The honest assessment

The evidence from observational studies of other GLP-1 receptor agonists has been mixed, with some studies showing no increased risk while others suggest a possible small increase in thyroid cancer diagnoses, though causality remains uncertain

The dual mechanism generally produces greater weight loss than semaglutide, a finding that is consistent across head-to-head comparisons and meta-analyses in the published literature

Journal Of Diabetology

Doses for the 2G formulation were selected based on a previous comparative bioavailability study (NCT04097600) [27]