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Further, clinical trial studies of MK-677 have been conducted to improve body composition and metabolism in older adults11 or to increase bone mass in obese young males and older adults.12, 13 However, the beneficial effect of MK-677 on growth promotion in children is controversial

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doi: 10.1007/s10875-012-9708-x 327 ChenKZengKJinSMaYCaiLXuPet al