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However, its non-selective agonist action raises safety concerns, notably the potential risk of renal infarction

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The pathogenesis of cerebral circulation disorders caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, impaired neurotransmitter systems, and vascular pathologies that lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia [27]