More details about this study by National Library of Medicine
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As treatment continues, weight loss shifts primarily to fat mass reduction, which occurs more slowly
So when you remove the GLP-1 medication, that patient is set back on a course of weight increase. In other words, without the medication to block and promote pathways that can affect a bodys biochemistry, a person is more likely to return to consuming more calories and regaining weight
When injected once weekly, semaglutide binds to GLP-1 receptors in the brain's satiety centers, reducing hunger signals and increasing feelings of fullness
The adjusted protocol above start earlier, smaller and more frequent doses, liquid-first is what I am training with and what I plan to race with