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Patients receiving L-carnitne showed significant improvement compared to the placebo group

10.1016/j.heliyon.2023.e21227 Heliyon

Current serotonin medications are aimed at increasing central 5-HT neurotransmission in the brain, and there are no approved indications for manipulating peripheral 5-HT, though peripheral 5-HT synthesis is being considered as a potential target for developing pharmacological agents in some disorders ( We are not aware of prior studies reporting low S-5-HT in hypothyroidism or CFS

There were 69 subjects in the placebo group and 62 in the hydrolyzed collagen group

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Bacteriostatic water is sold separately and is recommended for laboratory reconstitution work over plain sterile water for solutions stored beyond 24 hours