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Electrospray ionization in positive mode and multiple reaction monitoring are applied for detection

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Needless to say, this is a topic the researchers tackled

The resulting holoenzyme dimer comprising the two subunits is catalytically more efficient and less subject to inhibition by GSH than GCLC alone

Based on in vitro studies, CYP3A4 and CYP2D6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and N-dealkylation is catalyzed by CYP3A4