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10.1038/s41419-022-04527-z Cell Death Dis

doi: 10.1186/s11658-022-00320-0 103 ImranMRaufAKhanIAShahbazMQaisraniTBFatmawatiSet al

All statistical tests were two-sided and used a significance level of P 4000 observations additionally including an additional sample with data collected in subjects still available at 6-year follow-up

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Most of what we know comes from animal models

Hormone Replacement Therapy (HRT): The Stepwise Method Instead of jumping into full hormone replacement, McCall recommends a phased approach: Prioritize Based on Symptoms: Progesterone: For anxiety, insomnia, heavy periods, mood swings Testosterone: For low libido, energy issues, muscle loss Estrogen: Last to drop, often during peri/menopause Action Plan: Begin with the hormone causing the most distress