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The STEP 1 clinical trial shows that semaglutide users lost 14.9% of their body weight with 2.4 once weekly semaglutide after 68 weeks when combined with lifestyle modifications and a reduced calorie diet

Here are the top five, highlighting their unique advantages along with scores out of 100: The Mediterranean diet is a balanced, plant-focused approach inspired by traditional foods from Greece, Italy, and Spain

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However, this is not suitable for people who are only a little overweight with no weight-related medical conditions

Ipamorelin: Ideal for those seeking anti-aging benefits, enhanced recovery, or improved physical performance

doi: 10.1038/s42003-025-07541-x 142