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Earlier incretin-based medicines focused mainly on GLP-1 receptor signaling, while newer investigational compounds explore whether combining GLP-1, GIP, and glucagon pathways can produce distinct metabolic effects

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Similar content being viewed by others Introduction Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) have become central to the management of type 2 diabetes mellitus (T2DM)

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