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The authors call for long-term studies to assess the impact of GLP-1 RAs on cardiovascular safety, bone health, growth, pubertal development, and other long-term outcomes, helping define their role in the long-term management of pediatric metabolic disease

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[19] A study published in Obesity found that pre-meal water consumption contributed to greater weight loss in dieters

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However, prolonged exposure to FFAs hampers glucose-induced insulin secretion and insulin production, potentially resulting in apoptosis-mediated -cell death

In our experience, the rate at which patients are willing and able to stay on treatment depends less on the medication itself than on how their clinical team responds to symptoms