While data has been mainly retrospective, it has ranged from specific patient groups, such as those with hormone receptorpositive disease receiving endocrine therapy 1 or those only receiving semaglutide and tirzepatide with stage I to III breast cancer, 2 to patients from the broader breast cancer population receiving a range of GLP-1 agonists
Injectable versions of these medications must be refrigerated, but some reports indicate shipments have arrived warm or without adequate cooling, potentially compromising effectiveness
Its important to note that your starting dose can vary based on your health history, other medications, side effects, and goals
Divi's Laboratories is already supplying semaglutide components globally Price compression will occur Not immediately, and not to generic-drug levels, but a ~50% reduction from current branded pricing is a reasonable baseline expectation based on biosimilar precedent in other biologic classes New formulations will compete Novo Nordisk's oral semaglutide (approved December 2025 by the FDA and launched in early 2026) and the newly FDA-approved once-daily oral GLP-1 orforglipron (Foundayo, approved April 1, 2026) represent the manufacturer's strategy for maintaining market share through innovation beyond the injectable The arrival of biosimilar competition does not mean branded products disappear
If youre injecting compounded semaglutide, pinch and hold the skin that youll inject
So it may increase some risk if people are going to go to sources outside of the U.S