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Following OA induction, the rabbits were randomly divided into four groups with 8 subjects, each receiving a different weekly intra-articular treatment starting four weeks after the first collagenase injection

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These findings remain preliminary and require further investigation

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2 hrs after reaching the maximum plasmatic concentration, the concentration of active drug is higher in the synovial fluid than in the plasma and the rest is reached in a period of 12 hrs

Certain medical conditions People with peripheral neuropathy in the legs may have reduced sensation that makes it difficult to judge injection depth and placement correctly