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105 Historically considered to be cytosolic, CBS and CSE can alsounder certain (patho)physiological conditionstranslocate to mitochondria 108,109 or nuclei, 110 or even be secreted

These differences likely reflect local tissue binding, lymphatic uptake, and first-pass metabolism variations between administration sites and species

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Thereby, we argue that the better hemostasis was achieved with BPC 157 administration, the balanced role of the L-arginine and of the L-NAME and the more rescued NO-hemostatic mechanisms