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Quality assessment: RCTs were evaluated using Cochrane RoB 2

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Recent research into ME/CFS investigates increased kynurenine production rather than decreased levels proposed by the metabolic trap hypothesis. The balance between tryptophan depletion and kynurenine generation, marked by the kynurenine and tryptophan (KYN/TRP) ratio, indicates IDO activity and immune responses

From there it is one injection a week, with the slow, provider-set titration described above

Total body skin examination for skin cancer screening in patients with focused symptoms

Treatment options include topical erythromycin or clindamycin, Whitfields ointment, and sodium fusidate ointment