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In epilepsy, ketogenic dietary therapy is an established treatment, particularly for infantile, refractory, and metabolic epilepsies such as glucose transporter type 1 (GLUT1) deficiency and pyruvate dehydrogenase deficiency, where ketosis may reduce seizure frequency and severity, potentially via enhanced mitochondrial efficiency and dampened excitatory synaptic transmission, although mechanisms remain incompletely understood [67, 69, 70, 71]

The medication is not recommended for long-term use, generally limited to a maximum of 12 weeks

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Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinsons disease