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This is a complex syndrome that includes the following symptoms besides pain: fatigue, sleep disturbances, and functional symptomsmedical conditions with no structural or pathological cause [1]

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It describes candidates as people with severe obesity above a BMI of 40 who have plateaued on monotherapy, have robust liver and kidney function, tolerate each agent individually, and are motivated for intensive monitoring

Because the cost of care rises as patient comorbidities increase, the value of treatment also increases

(September 2008)