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On the other hand, certain SCFAs under specific conditions might contribute to pathology: for example, a recent study found that butyrate and propionate can activate the NLRP3 inflammasome in human macrophages under inflammatory stress, suggesting a potential pro-inflammatory role in some contexts [78, 79]

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The effect of vitamin A supplementation on stimulated T-cell proliferation with myelin oligodendrocyte glycoprotein in patients with multiple sclerosis