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For example, in the peroxisome where verylongchain FAs are preferentially metabolized, carnitine shuttles the fatty acyl end products of beta oxidation between the peroxisome and the mitochondria (Steiber et al., 2004)

However, in contrast to rhEPO that has shown side effects in clinical trials, to date ARA 290 has been shown to be safe when formally evaluated in preclinical animal toxicology, normal human volunteers and patients with sarcoidosis (1921)

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doi: 10.1093/ibd/izz007 24 UrsiniFMaiorinoM

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However, due to the deregulation of cells and increased cell death, glutathione deficiency is often observed in those with autoimmune diseases, arthritis, asthma, and even Parkinson's disease