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Both openings could provide access to the catalytic triad, as they have negative electrostatic potential and would attract the positively-charged N-terminus of the short bioactive peptide substrate (Rasmussen et al., 2002)

& Plouet, J

Women with lipedema who have a feeling of heaviness in their legs, obvious edema, chronic venous insufficiency or Stage II and III lipedema report feeling less pain and improved swelling on diosmin based on the authors experience

Lousse JC, Defrre S, Van Langendonckt A, Gras J, Gonzlez-Ramos R, Colette S, et al

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TB-500 gilt nicht als klassisches Muskelaufbauprparat