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c) Manhattan plot of experiencing nausea while on GLP-1 treatment

These findings support the notion that, similar to the development of peripheral opioid receptor antagonists, developing therapeutic targeting specific brain regions is one of several avenues that warrant exploration for patients unresponsive to current therapies

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These changes in metabolites not only act as biomarkers for depression but may also offer novel insights into the pathogenesis of the condition

Monitoring should include regular lab testing and symptom assessment