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Experimental evidence shows that dietary Trp supplementation improves motor deficits, enhances tyrosine hydroxylase expression, inhibits NF-B activation in the substantia nigra, and lowers circulating pro-inflammatory cytokines in toxin-induced, animal PD models [167]

Mechanically: if only pathway 1 is activated, initiation occurs without triggering

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For those who are unfamiliar, Parkinson's disease is a progressive neurological disorder in which changes to certain tissues in the brain have an adverse effect on movement