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Peutz-Jeghers syndrome Peutz-Jeghers syndrome is a rare, inherited condition characterised by hyperpigmentation around the mouth and on the lips, as well as the fingers and toes

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In addition, insulin has multiple other roles observed in tissue studies and animal models of AD, including effects on synaptic plasticity, dendritic spine formation, transmitter turnover, proteostasis including clearance of A and tau, vascular function, lipid metabolism, and inflammation [96]

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