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Locketz GD, Bloom JD

Long-term maintenance treatment achieves seizure freedom in 69% of patients, with PN in combination with antiseizure medications having the best efficacy

The result in phase 2 clinical trials was 24.2% mean body weight reduction at 48 weeks with the 12mg dose, and the first phase 3 TRIUMPH-4 trial reported an average of 28.7% weight loss at 68 weeks

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Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2-dependent silencing of SLC7A11