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MR-PRESSO identified outliers for autism and major depression, but no global pleiotropy was detected for other outcomes (Supplementary Table S5)

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Furthermore, the effect of 50 mmol l 1 propionate on gut hormone release remained highly significant when compared with an iso-osmotic NaCl control (Figures 1b and d)

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The mTOR/AKT inhibitor temsirolimus prevents deep infiltrating endometriosis in mice

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Moving to the ability of metformin to reduce the metastatic potential, it was demonstrated that the drug not only reduced the migration of MTC cancer cells (Klubo-Gwiezdzinska et al., 2012), but also modified the expression of several markers of the epithelial-tomesenchimal-transition (EMT) (Han et al., 2015)

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