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This raises intracellular calcium levels, triggering smooth muscle contraction
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Attacks on sugar groups may result in strand breaks, whereas attacks on histones may result in crosslinks that interfere with chromatin folding, DNA repair, and transcription
Taken together, these findings indicated that hepsin / mice experience heightened oxidative stress in the early stages of APAP exposure, suggesting that endogenous hepsin might protect against toxicity during the early stages of APAP exposure, thereby significantly influencing survival outcomes in drug-induced toxicity cases
