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Furthermore, fibrosis severity correlated with smoking index and coexistent diabetes, reinforcing a dose-dependent effect

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In some experiments, 48c (20 or 40 mg/kg, MedChemExpress) and liproxstatin-1 (10 mg/kg, Cayman Chemical), both given in 16% (v/v) Cremophor EL (Sigma Aldrich) saline solution, were intraperitoneally injected into mice daily for 3 days before IRI and the surgical procedure was performed on the day following the last drug injection

Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016)

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pka3 = 8.7 SH HO pKa1 = 2.1 NH3 pka4 = 9.1 SH