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Zone 3 represents the posterior compartment along with the posterior uterine serosa, the pouch of Douglas, the posterior vaginal fornix, and the bowel

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The aberrant downregulation of SMO-SHH signals contributes to the proteolytic cleavage of GLI (glioma-associated homolog) into GLI3 (repressor), which increases oxidative stress, neuronal excitotoxicity, neuroinflammation, and apoptosis by suppressing target gene expression

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