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Acute phase proteins (APPs) as salivary biomarkers Chronic subclinical inflammation and tissue injuries are associated with the secretion of acute phase proteins, such as haptoglobin (Hp), CRP, Alpha 1-antitrypsin (A1AT), fibrinogen and ferritin, mainly from the liver into the bloodstream

Notably, alterations in cholinergic signaling, neuroinflammation involving microglial activation, and calcium dysregulation have emerged as relevant contributors to AD pathogenesis

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