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As glucagon-like peptide 1 receptor agonists (GLP-1RAs), such as semaglutide and tirzepatide, become increasingly central to diabetes care owing to their cardiometabolic benefits, there is growing interest in their potential to offer broader protection against neurological and cerebrovascular complications in this vulnerable population

It is worth noting that fatigue may also be coincidental and unrelated to GLP-1 therapy, arising from underlying conditions such as anaemia, thyroid dysfunction, depression, or sleep disorders

CrossRef Characteristics of cardiovascular autonomic dysfunction and association with quality of life in patients with systemic lupus erythematosus Amanda Hempel Zinglersen, Katrine Kjr Iversen, Henrik Christian Bidstrup Leffers, Esben Laugesen, Jesper Fleischer, Sren Jacobsen Lupus Science & Medicine.2021

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In Arabidopsis, only the plastidial GR2 is essential (Marty et al., 2019)