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According to the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), gastrointestinal disturbances occur in a significant proportion of patients, with nausea affecting up to 20% of users

Yu, X., et al

Its the person who is no longer metabolically flexible who is having an acceleration in aging due to glycation produced in the body and by not clearing AGEs from the diet

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In OA, elevated levels of Lipid-ROS are closely linked to chondrocyte death and cartilage degradation