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On the other hand, the reduction of monoamine neurotransmitters availability caused by reserpine can lead to negative side effects associated with depression, pain signal processing abnormality, cognition impairment, and motor activity alteration 32,33,34

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Reported Effects Weight reduction (no diabetes): In REDEFINE 1, CagriSema 2.4 mg + 2.4 mg produced roughly 22.7% mean weight loss at 68 weeks (trial-product estimand), though this fell short of the ~25% Novo Nordisk had guided toward [1]

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USA 103 , 1249312498 (2006)

Methods Study design and procedures Ethical approval was obtained from the London City & East Research Ethics Committee (Reference: 21/LO/0334), and the study was jointly sponsored by Kings College London and South London and Maudsley NHS Foundation Trust