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Altered SDF-1-mediated differentiation of bone marrow-derived endothelial progenitor cells in diabetes mellitus

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) Cardiovascular symptoms rapid heart rate chest pain palpitations shortness of breath Severe allergic reactions swelling of face, lips, or throat difficulty breathing widespread rash or hives Severe abdominal pain, vomiting, or signs of dehydration These may reflect toxicity or contamination of the product

These authors found that toxic IAPP oligomers initially appear within the granules in the secretory pathway, where they disrupt the membranes of the granules, leading to their release into the cytoplasm