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Major barriers to the clinical use of gene therapy, however, include transfection efficiency, the creation of long-term effects, the difficulty of controlling cell proliferation, ectopic transfection, disease transmission, patient-specific dose responses, immune reactions against viral proteins, possible side effects, and ethical issues [87, 88]

In essence, the regulation of energy metabolism as a therapeutic strategy shows considerable promise amidst challenges and hope

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An abundance of amino acids such as glutamate, glycine, alanine, aspartate, serine, threonine, and histidine, are active in the liver

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4 Ferroptosis: a novel therapeutic target It has been evident that during the process of ferroptosis, alterations in pathogenesis profoundly affect the normal workings of retinal cells, retinal architecture, and vascular remodeling