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The headline weight-loss numbers Analyzed by planned treatment, mean body-weight change from baseline to week 46 was dose-dependent: about 6.2% at 0.6 mg, 12.5% at 2.4 mg, 13.2% at 3.6 mg, and 14.9% at the top 4.8 mg dose, compared with roughly 2.8% for placebo

Sustained overeating, even for muscle-building reasons, gradually dulls insulin sensitivity

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For patients whose primary goal is weight management alongside diabetes control, NICE guidance (NG28) supports considering SGLT2 inhibitors, which are generally weight-neutral or beneficial

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