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Kidney Int (2022) 102(2):395404

doi:10.1038/npjbcancer.2016.26 Ligibel JA, Barry WT, Alfano C, et al

After the initial Phase III studies showed the GLP-1/GIP agonists effectively lowered hemoglobin A1c levels, several influential randomized trials were published investigating their effects on cardiovascular outcomes in diabetic patients

A lot of it flows from pathways that depend on healthy NAD+ status, including the pentose phosphate pathway

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Common early side effects include mild nausea, reduced appetite, and occasional constipationmost resolve within 12 weeks as your body adapts