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The STEP 1 trial showed an average weight loss of 14.9% of starting body weight over 68 weeks at this dose

[6] However, GLP-1 RAs have been associated with increase in patient heart rate, eliciting concern for arrhythmias

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Researchers in BMJ reviewed almost 10,000 reports of the use of weight loss medications or behavioral programs, and identified 37 studies with low risk of bias (with 9,431 participants) on which to perform a meta-analysis

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