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Summary: Vitamin B12 supplementation does not directly cause joint pain, and no established causal link exists in medical literature

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Acknowledgements We thank A Wright, D Horng, and P Sanchez for supporting studies in this manuscript

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Importantly, chronic treatment with P5 did not induce hepatocellular toxicity as reflected by the absence of changes in plasma level of alanine aminotransferase, alkaline phosphatase and aspartate aminotransferase (Fig

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