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For context, tirzepatide 15 mg in the SURMOUNT trials had discontinuation rates around 6-7%

Research generally suggests that the risk of nausea is less with other GLP-1 medications, such as semaglutide (the active ingredient in Ozempic and Wegovy )

That is a decision that involves weighing effectiveness against commitment, monitoring, and long-term safety data

de Sa Junior PL, Camara DAD, Porcacchia AS, Fonseca PMM, Jorge SD, Araldi RP, Ferreira AK

The study also found that meal composition blood alcohol effects were visible not just in measured BAC levels but in objective psychomotor performance tests meaning the reduced peak BAC from eating translated to measurably less cognitive and physical impairment