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4 Clinical applications and efficacy evaluation 4.1 Viral hepatitis High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that promotes inflammatory responses in viral hepatitis

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DMSA is FDA-approved for the treatment of lead poisoning in children as young as 2 years, and this study investigated its use for an off-label application, namely treating children with ASD who have evidence of significant heavy metal exposure (based on urinary excretion after DMSA challenge)