Similarly, GluCEST detected altered brain glutamate concentration in patients with schizophrenia and temporal lobe epilepsy [142, 143]
By aligning diagnosis and prescription, we can reduce adverse events, improve patient outcomes, and meet NABH safety benchmarks
Research teams at MSK are actively pursuing this approach
Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition
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It makes it under-enforced