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Symptomatic awareness of hypoglycemia may be less pronounced in patients with longstanding diabetes in patients with diabetic nerve disease, in patients using medications that block the sympathetic nervous system (e.g., beta-blockers) [see Drug Interactions (7)], or in patients who experience recurrent hypoglycemia

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It also plays an important role in maintaining proper immune function

doi: 10.1038/nn1969 172 SalcedoI.TweedieD.LiY.GreigN