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Use of DPP-4 inhibitors has been associated with an increased risk of inflammatory bowel disease compared with other diabetes drugs (53.4 vs

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It is well described that relatively high doses of anti-PCSK9 antibodies, as for instance 140 mg every two weeks of evolocumab, are required to overcome the antigen sink 37,38

Anti-inflammatory mechanisms may play a role here, as chronic inflammation contributes to glomerular injury and tubulointerstitial fibrosis

Conclusion Compared with placebo, GLP-1 RAs may reduce the risk of MACE in patients with HF coexisting with T2DM, with a more significant efficiency of human GLP-1 RAs