GLP-1 Success Story GLP-1 agonists (also called GLP-1RAs), and related drugs like dual agonists of gastric inhibitory polypeptide (GIP)/GLP-1, have revolutionized obesity treatment by demonstrating significant and sustained weight loss in clinical trials and real-world use
Discontinuation rates 8.7-9.7%
Evidence-based alternatives include optimising nutrition with iron-rich foods and complex carbohydrates, taking recommended supplements such as vitamin D (10 micrograms daily), addressing iron deficiency if confirmed by blood tests, ensuring adequate hydration, and prioritising sleep when possible
One example is drinks formulated with coffee, green tea extract or added protein to reduce hunger
For tirzepatide (Mounjaro SmPC, MHRA/EMC), arthralgia is similarly listed
Frequently Asked Questions What exactly is Retatrutide being researched for