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In 2001, Prkacin et al

It was demonstrated that in the spinal cord of the SOD1-G93A ALS mouse model, the mitochondrial receptor SQSTM1/p62 is recruited to the mitochondrial surface, where it activates mitophagy, whereas knockdown of the Parkin gene reduces the loss of motor neurons, thereby delaying the progression of disease in SOD1-G93A mice (Palomo et al., 2018)

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Popular Pathways were identified by analyzing trends in dementia-related publications over the past 10 years using Pathway_ranks (the rank of the pathways based on their yearly count of the literature related to AD)

No human joint trials

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