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Apart from binding SUR1, Epac2 also binds to a series of molecules that potentially participate in transport, priming and fusion of the insulin vesicles, including Rab3, Rim2, and the Ca 2+ sensor Piccolo [493,512,513]
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I've heard that tablets may go through our system without dissolving
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GI symptom rates at the 12 mg dose included nausea (38-43%), diarrhea (33-35%), constipation (21-25%), and vomiting (20-21%)
However, subsequent controlled studies showed variable results
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