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Senescent mitochondria not only produce more ROS due to inefficient electron transport but also exhibit impaired iron-sulfur cluster biogenesis, leading to improper iron handling and accumulation within the mitochondria, thus creating a potent internal source of oxidative stress (106,107)
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Beta-Thalassemia intermedia: a comprehensive overview and novel approaches
Biomed Pharmacother 90:500508 Jagadeesh GS, Nagoor Meeran M, Selvaraj P (2016) Protective effects of 7-hydroxycoumarin on dyslipidemia and cardiac hypertrophy in isoproterenolinduced myocardial infarction in rats
As mentioned in the Introduction, both lowered SpO2 and increased body temperature are part of the immune-inflammatory response, predict critical illness and death, and are manifestations of the infectious-immune-inflammatory core of acute COVID-19 [94]
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