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Mol Metab 11:8495 Tolhurst G et al (2012) Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2

Bull Exp Biol Med 2003;135:4958

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Key findings relevant to nausea included: Nausea was most prevalent during the dose-escalation phase and tended to diminish over time as participants adapted to the medication Higher doses were associated with higher rates of nausea and vomiting The majority of gastrointestinal events were transient and self-limiting Discontinuation due to gastrointestinal side effects occurred in a small but notable proportion of participants, particularly in higher-dose groups It should be noted that the weight-loss outcomes described above are from a Phase 2 trial and cannot be directly compared with those of licensed medicines without head-to-head data

For example, semaglutide treatments usually start at 0.25 mg weekly and increase to maintenance doses of 1.0 mg or higher, depending on the specific medication and condition being treated